2015•Practical Journal of Cardiac Cerebral Pneumal and Vascular DiseaseRequires access
Clinical Effect of Xuezhikang Capsule on Angina Pectoris in Patients with Coronary Heart Disease
Han Hong-chen
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Abstract
Objective To analyze the clinical effect of xuezhikang capsule on angina pectoris in patients with coronary heart disease.Methods A total of 80 patients with coronary heart disease and angina pectoris were selected in the Central Hospital of Xi' an from November 2013 to November 2014,and they were randomly divided into observation group and control group,each of 40 cases.Patients of control group were treated with conventional therapy,while patients of observation group were treated with xuezhikang capsule on the basis of conventional therapy.Frequency of angina pectoris attack,episode of angina pectoris,nitroglycerin dosage were observed during treatment;whole blood specific viscosity and plasma viscosity between the two groups were compared before and after treatment;Doppler echocardiography was used to detect LVEF,ELISA was used to detect the serum VEGF level.Results The clinical effect of observation group was statistically significantly better than that of control group(u =-3.189,P = 0.001).No statistically significant differences of frequency of angina pectoris attack,episode of angina pectoris or nitroglycerin dosage was found between the two groups before treatment(P 0.05);while frequency of angina pectoris attack of observation group was statistically significantly lower than that of control group,episode of angina pectoris of observation group was statistically significantly shorter than that of control group,nitroglycerin dosage of observation group was statistically significantly less than that of control group after treatment(P 0.05).No statistically significant differences of LVEF or serum VEGF level was found between the two groups before treatment(P 0.05);while LVEF and serum VEGF level of observation group were statistically significantly higher than those of control group after treatment(P 0.05).No statistically significant differences of whole blood specific viscosity or plasma viscosity was found between the two groups before treatment(P 0.05);while whole blood specific viscosity and plasma viscosity of observation group were statistically significantly lower than those of control group after treatment(P 0.05).Conclusion Xuezhikang capsule has certain clinical effect on angina pectoris in patients with coronary heart disease,which can effectively improve the blood supply of myocardium,reduce the blood viscosity and improve the hemorheology.