Study on clinical of Ulinastatin in treating patients with Acute Organophosphorus Poisoning

Objective To explore the efficacy of Ulinastatin in treating patients with Acute Organophosphorus Poisoning(AOPP).Methods Twenty-three patients with AOPP were randomly assigned to the study group and the control group.Patients in the study group were given Ulinastatin treatment plus standard treatment while patients in the control group received standard treatment only.Physical indexes of heart rate,respiratory rate,temperature and white blood cell count,blood biomedical indexes of C-reactive protein and serum cholinesterase activity,the scores of the Acute Physiology and Chronic Health Evaluation II(APACHEII),incidence of Multiple Organ Dysfunction Syndrome(MODS) and mortality were measured and assessed.Results Physical indexes of HR,RR,T and WBC in both group had improved greatly after treatment,and the improvement of outcome in the study group was better than that in control group(P0.05).Blood biomedical indexes of CPR and ChE in both groups had declined significantly at day 5 for treatments,and there was better outcome in the study group than in the control group.Score of APACHEII in the study group was lower than that in control group(P0.05).Incidence of MODS and mortality from the condition in the study group was less than those in control group(P0.05).Conclusion Ulinastatin could be used to stop the deteriorating of AOPP to MODS and reduce the mortality of the condition based on standard treatment.