Expression of PTEN and IGF-1R and relationship with clinicopathological factors in laryngeal squamous cell carcinoma

Objective To detect the expression of PTEN protein and IGF-1R protein in the laryngeal squamous cell carcinoma(LSCC),and to analyze relationship with LSCC' clinicopathological factors.Methods To take 50 pieces of petroline samples of laryngeal squamous cell carcinoma as study object.to take 30 pieces of VCP mucosae samples as control group.To detect the expression of PTEN protein and IGF-1R protein in LSCC and VCP by S-P immunohistochemistry method,to analyze the relationship with histology differentiated degree,T grade,clinical stage and lymph node diversion of LSCC.Statistic analyses were done by SPSS 13.0 software.Results The positive rates of PTEN were respectively 58%,96.7% in LSCC,and VCP,there were notable significant difference between them statistically (P0.01).With increasing of T grade,clinical stage and lymph node diversion,the positive rates of PTEN were basically gradually cutting down.The positive rates of IGF-1R were respectively 68%,16.70% in LSCC,and VCP,there were notable significant difference between them statistically (P0.01).With increasing of T grade,clinical stage and lymph node diversion,the positive rates of IGF-1R were basically gradually rising.PTEN expression was obviously negative correlation with IGF-1R expression.Conclusions Absence and/or deactivation of PTEN and overexpression of IGF-1R are probably section of LSCC' disease mechanism,there is probably disequilibrium between PTEN and IGF-1R,and this disequilibrium probably play a role in LSCC.