Relationship between Serum High Sensitivity C-Reative Protein and Atherosclerosis in Patients with Diabetes Mellitus

Objective:To explore the role of high sensitivity C-reative protein(hs-CRP) in atherosclerosis in patients with type 2 diabetes mellitus.Methods:141 patients with type 2 diabetes mellitus were divided into 3 groups according to aggregation of cardiovascular major risk factors.The thickness of carotid intima-media was measured and the percentage of plaque was calculated to reflect the extent of atherosclerosis.Levels of serum hs-CRP,lipids,insulin,glucose,blood pressure,bodymass index(BMI) were measured.Result:The more risk factors the more higher levels of BMI,triacylglycerol(TG),HOMA-Insulin Resistance(HOMA-IR),hs-CRP.The mean carotid intima-media thickness(IMT) were 0.68 mm,0.82 mm,0.97 mm and the percentage of plaque were 12.5%,24.1%,42.9% in the groups with the increased number of risk factors respectively.The carotid IMT was significantly different between the groups,but the precents of plaque was not different between the groups.The carotid IMT had positive relation with shrink blood press(SBP),HOMA-IR,hs-CRP.hs-CRP had positive relation with carotid IMT,HOMA-IR,TG and BMI.hs-CRP and HOMA-IR were the independently factors induced the atherosclerosis.Conclusion:There is a close relationship between level of hsCRP with HOMA-IR,IMT,hs-CRP can be as risk factor of atherosclerosis in patients with T2DM.