Experimental Study of Kingwolam in Regulating on Rat Gastrointestinal Motor Function

Objective:To study the influence of Kingwolam formula and its product on mouse small intestinal propulsion,gastric emptying and defecation,and to explore its effect on gastrointestinal motor function. Methods:The mouse small intestinal propulsion rate,the beginning time of defecation and the times of defecating melena during 6 hours were observed for the evaluation of effect of Kingwolam prescription and the product on mouse small intestinal propulsion and defecation function. The gastric residual rate of methyl orange in mice was examined for the evaluation of the function of gastric emptying. Results:High- dose Kingwolam formulaⅠ,high- and low- dose Kingwolam formulaⅡ, and Kingwolam product showed an effect on increasing small intestinal propulsion rate,promoting the first defecation, and reducing the gastric residual rate of methyl orange(P 0.01 or P 0.05 compared with those in the blank control group). Conclusion: Kingwolam formula and its product can significantly regulate the gastrointestinal motor function in mice.