Impacts of Early-stage Large-dose Simvastatin on High Sensitive C-reactive Protein of Elderly Acute Coronary Syndrome

Objective To observe the impact of blood lipid reduction by large-does Simvastatin on the high C-reactive protein of elderly acute coronary syndrome.Methods Divide elderly acute coronary syndrome patients admitted in our hospital from 2007 to 2009 into two groups,one group was treated with Simvastatin 40mg/d and the other group with conventional 20mg/d Simvastatin.We examined their serum high sensitive CRP(hs-CRP) and blood lipid and observed the impact of Simvastatin on both groups.Results The differences of serum hs-CRP in the two groups had statistical significance(P0.05).Conclusion For ACS patients,both 20mg/d and 40mg/d Simvastatin are effective on reducing hs-CRP and blood lipid,40mg/d Simvastatin has better effects in reducing hs-CRP and cardiovascular incidents.Reducing blood lipid of elderly acute coronary syndrome at early stage can help reduce terminal occurrence rate.