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Clinical Observation of Magnesium Isoglycyrrhizinate Injection Preventing Acute Liver Injury Induced by Chemotherapy Drugs

Xiuhua Ren

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Abstract

OBJECTIVE:To observe the effects of Magnesium isoglycyrrhizinate injection preventing acute liver damage induced by chemotherapy drugs. METHODS:94 patients with malignant tumor suffered from Ⅱ degree drug-induced liver injury after first chemotherapy cycle then were cured after liver protection treatment. Treatment group was treated with Magnesium isoglycyrrhizinate injection 150 mg (47 cases) and control group was treated with Reduced glutathione injection 1.2 g (47 cases) once a day for 2 weeks during the second chemotherapy cycle. The treatment which was lower than Ⅱ degree drug-induced liver injury was effective. RESULTS:After treatment, the effective rates were 80.9% for treatment group and 55.3% for control group (P0.01), and the contents of ALT were (20.8±9.4)U·L-1 and (35.4±7.1)U·L-1 respectively (P0.05). CONCLUSION:Magnesium isoglycyrrhizinate injection can prevent acute liver injury induced by chemotherapy drugs effectively.

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OBJECTIVE:To observe the effects of Magnesium isoglycyrrhizinate injection preventing acute liver damage induced by chemotherapy drugs. METHODS:94 patients with malignant tumor suffered from Ⅱ degree drug-induced liver injury after first chemotherapy cycle then were cured after liver protection treatment. Treatment group was treated with Magnesium isoglycyrrhizinate injection 150 mg (47 cases) and control group was treated with Reduced glutathione injection 1.2 g (47 cases) once a day for 2 weeks during the second chemotherapy cycle. The treatment which was lower than Ⅱ degree drug-induced liver injury was effective. RESULTS:After treatment, the effective rates were 80.9% for treatment group and 55.3% for control group (P0.01), and the contents of ALT were (20.8±9.4)U·L-1 and (35.4±7.1)U·L-1 respectively (P0.05). CONCLUSION:Magnesium isoglycyrrhizinate injection can prevent acute liver injury induced by chemotherapy drugs effectively.

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Available abstract

OBJECTIVE:To observe the effects of Magnesium isoglycyrrhizinate injection preventing acute liver damage induced by chemotherapy drugs. METHODS:94 patients with malignant tumor suffered from Ⅱ degree drug-induced liver injury after first chemotherapy cycle then were cured after liver protection treatment. Treatment group was treated with Magnesium isoglycyrrhizinate injection 150 mg (47 cases) and control group was treated with Reduced glutathione injection 1.2 g (47 cases) once a day for 2 weeks during the second chemotherapy cycle. The treatment which was lower than Ⅱ degree drug-induced liver injury was effective. RESULTS:After treatment, the effective rates were 80.9% for treatment group and 55.3% for control group (P0.01), and the contents of ALT were (20.8±9.4)U·L-1 and (35.4±7.1)U·L-1 respectively (P0.05). CONCLUSION:Magnesium isoglycyrrhizinate injection can prevent acute liver injury induced by chemotherapy drugs effectively.

Key concepts: Medicine, Chemotherapy, Liver injury, Drug, Gastroenterology, Glutathione, Magnesium, Internal medicine

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