2012•Journal of Clinical Medicine in PracticeRequires access
Efficacy of magnesium isoglycyrrhizinate in prevention of chemotherapy drug-induced liver injury in patients with acute leukemia
Jiangang Yang
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Abstract
Objective To observe the efficacy of magnesium isoglycyrrhizinate in prevention of chemotherapy drug-induced liver injury in patients with acute leukemia.Methods Sixty-six patients with acute leukemia were randomly divided into prevention group(n=34) and control group(n=32).The prevention group received chemotherapy drugs combined with magnesium isoglycyrrhizinate and the control group only received chemotherapy drugs.Results There was 15 cases(9.6%) with liver injury in the prevention group,and 46 cases(31.7%) in the control group.The difference between the two groups was statistically significant.The efficacy rate of liver injury prevention was 82.7% in the prevention group,and 22.7% in the control group.There was significant difference between the two groups.Magnesium isoglycyrrhizinate-related adverse reactions in the course of treatment were not observed.Conclusion Magnesium isoglycyrrhizinate is effective in prevention of chemotherapy drug-induced liver injury in patients with acute leukemia.Thus it is worthy of promotion.