Application of High-volume Hemofiltration for Patients With Sepsis Complicated With Multiple Organ Dysfunction Syndrome

Objective:To investigate the therapeutic effect of high-volume hemofiltration(HVHF)for patients with sepsis complicated with multiple organ dysfunction syndrome(MODS).Methods:Thirty-nine cases with sepsis complicated with MODS were studied retrospectively.Plasma level of interleukin-6(IL-6)was compared between death and survival group.Serum creatinine,blood urea nitrogen(BUN),oxygenate index,lactic acid,mean arterial pressure,APACHE Ⅱscore were compared before and 24 hours after HVHF.Results:Serum IL-6 decreased significantly in two groups after HVHF(P0.01),but the serum IL-6 were significantly higher in non-survival group than that in survival group before and after HVHF(P0.01).Serum creatinine,BUN,oxygenate index,lactic acid and mean arterial pressure improved significantly in two groups 24 hours after HVHF(P0.01).APACHE Ⅱ score decreased significantly in survival group(P0.01).Conclusions:HVHF is an effective supportive measure for patients with sepsis complicating MODS,and it can eliminate IL-6 effectively.