Effect of high volume hemofiltration in severe sepsis patients with multiple organ dysfunction syndrome

【Objective】 To investigate the effect of high volume hemofiltration in sepsis patients with multiple organ dysfunction syndrome(MODS) 【Methods】 Twenty-six adult patients with severe sepsis patients with MODS were given HVHF(60 ml·(kg·h)-1),lasting 10-18 hours every day.Observed the patient's vital signs,Hemodynamics,Respiratory parameters,Liver and kidney function parameters,Arterial blood lactate,PCT and Acute physiology and chronic health evaluationⅡ(APACHEⅡ) scores,multiple organ dysfunction syndrome(MODS) evaluation scores,before and after treatment 【Results】 APACHE Ⅱ score,MODS score of patients receiving HVHF were significantly lower after treament,T,HR improved(P 0.05);Hemodynamics of the sepsis patients with multiple organ dysfunction syndrome(MODS) was significantly improved in 48 h,72 h of treatment;MAP,CI,SVI,SVRI tend to be stable,compared with before HVHF.there were significant differences(P 0.05);Respiratory,oxygen were improved,PaO2 and PaO2/FiO2 gradually increased to normal levels,in 48 h,72 h of HVHF treatment(P 0.05);Liver and kidney function were improved after HVHF;arterial blood lactate,PCT reduced to normal,in 24 h,48 h,72 h of HVHF treatment(P 0.05).【Conclusion】 HVHF can merge MODS in sepsis patients with stable vital signs,HVHF shows significant beneficial effects on Breathing and oxygen function of sepsis patients with MODS.HVHF improve hemodynamics,improve organ function and tissue perfusion.