The clinical application of high-volume hemofiltration in the patients with multiple organ dysfunction syndrome

Objective:To observe the effects of high-volume hemofiltration(HVHF)on the cytokines in the patients with multiple organ dysfunction syndrome and to investigate the therapitic action of HVHF for the patients with MODS.Methods:19 patients with multiple organ dysfunction syndrome were randomly divided into HVHF group(n=10)and CVVH group(n=9),the levels of serum tumor necrosis factor-α(TNF-α),interleckin-6(IL-6)and interleckin-8(IL-8)were measured by enzyme-linker immunoadsorbent assay(ELISA)before and after the therapy,and to observe the death rates and the levels of BUN and Scr.Results:Compared with that before the therapy,the average concentrations of plasma creatinine and urea were decreased significantly after HVHF or CVVH(P0.05).The level of TNF α,IL-6,IL-8 in two groups all decreased after HVHF or CVVH(P0.05);Compared with CVVH group,the level of TNF α,IL-6,IL-8 after the HVHF curing were lower(P0.05).Conclusions:HVHF could decrease the levels of inflammatory mediator in the patients with MODS,and improve the survival rate of MODS patients.