ScholarLens Back to search
2008•Medical InformationRequires access

Effect of 3-nitropropionic acid Preconditioning on ischemic reperfusion injury of skeletal Muscle in rat limbs

Deng Su-ya

Open publisher page 0 citations

Abstract

Objective To investigate the effect of 3-nitropropionic acid preconditioning on ischemia-reperfusion injury of skeletal muscle in rat limbs.Methods ischemic reperfusion model of the hindlimb was set up ,and 30 rats were randomly divided into three groups.Sham group , ischemia reperfusion control and 3-NPA group .The degree of muscle damage was measured by changes of MDA,CPK,LDH in plasma and the microstructure of gastrocnemius muscle were observed in every group.Result:The degree of plasma MDA,CPK,LDH in control and 3-NPA group were significantly higher than those in sham group.while the degree of plasma MDA, CPK,LDH in 3-NPA group were significantly lower than those in control group,and the microstructure of gastrocnemius muscle in 3-NPA group was significantly improved compared with control group.Conclusion 3-nitropropionic acid preconditioning has a protective effect on the skeletal muscle ischemia reperfusion injury.

About this research paper

What this paper is about

Objective To investigate the effect of 3-nitropropionic acid preconditioning on ischemia-reperfusion injury of skeletal muscle in rat limbs.Methods ischemic reperfusion model of the hindlimb was set up ,and 30 rats were randomly divided into three groups.Sham group , ischemia reperfusion control and 3-NPA group .The degree of muscle damage was measured by changes of MDA,CPK,LDH in plasma and the microstructure of gastrocnemius muscle were observed in every group.Result:The degree of plasma MDA,CPK,LDH in control and 3-NPA group were significantly higher than those in sham group.while the degree of plasma MDA, CPK,LDH in 3-NPA group were significantly lower than those in control group,and the microstructure of gastrocnemius muscle in 3-NPA group was significantly improved compared with control group.Conclusion 3-nitropropionic acid preconditioning has a protective effect on the skeletal muscle ischemia reperfusion injury.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the effect of 3-nitropropionic acid preconditioning on ischemia-reperfusion injury of skeletal muscle in rat limbs.Methods ischemic reperfusion model of the hindlimb was set up ,and 30 rats were randomly divided into three groups.Sham group , ischemia reperfusion control and 3-NPA group .The degree of muscle damage was measured by changes of MDA,CPK,LDH in plasma and the microstructure of gastrocnemius muscle were observed in every group.Result:The degree of plasma MDA,CPK,LDH in control and 3-NPA group were significantly higher than those in sham group.while the degree of plasma MDA, CPK,LDH in 3-NPA group were significantly lower than those in control group,and the microstructure of gastrocnemius muscle in 3-NPA group was significantly improved compared with control group.Conclusion 3-nitropropionic acid preconditioning has a protective effect on the skeletal muscle ischemia reperfusion injury.

Key concepts: Skeletal muscle, Gastrocnemius muscle, Medicine, Hindlimb, Ischemia, Reperfusion injury, Internal medicine, Anesthesia

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of 3-nitropropionic acid Preconditioning on ischemic reperfusion injury of skeletal Muscle in rat limbs — Research Paper | ScholarLens