The curative effect of moderate and severe ulcerative colitis treated by mesalazine combined with low molecule heparin

Objective:To evaluate the curative effect of ulcerative colitis treated by Mesalazine combined with low molecule heparin.Methods: 40 patients with moderate and severe ulcerative colitis were divided into 2 groups randomly.A group is control group,20 patients,mesalazine was given orally as 4g/d,four times a day;B group is experimental group,20 patients,mesalazine was given orally as 4g/d,four times a day,oral taken,combined with low-molecule heparin 5000U/bid subcutaneous injection for 1 week.The changes of serum CRP and it under colonscope were evaluated Results: The effective rate of the experimental group was a little higher than that of the control group.So there is no statistical significance.The complete remission rate of the experimental group is higher than that of the control group,there is statistical significance.The serum CRP value was decrease significantly in experimental group,even was still low in next 6 month.Conclusion: the effect of mesalazine combined with low molecule heparin was higher than that of mesalazine alone for the patients with moderate and severe ulcerative colitis and long-term therapeutic effect was very good.