Influence of Rosiglitazone and Mesalazine Combination for Ulcerative Colitis on IL-1β and TNF-α

Objective To investigate the influence of rosiglitazone and mesalazine combination on IL-1β and TNF-α in mild to moderate active ulcerative colitis.Methods 52 patients with mild to moderate active ulcerative colitis were enrolled our study,who were randomly divided into three groups:treatment group(n=18)with rosiglitazone and mesalazine oral,control group1(n=17) with mesalazine oral only,control group 2(n=17) with mesalazine oral and dexamethasone retention enema.After 4weeks,the changes of IL-1βand TNF-α in the serum of the 3 groups were detected by enzyme-linked immunosorbent assay(ELISA).Results The levels of IL-1β and TNF-α in 3 groups decreased significantly after treatment(P0.05).The descent in treatment group was more significantly than those of the two control groups(P0.05),but the difference between the two control groups was not significant(P0.05).Conclusion The combination of rosiglitazone and mesalazine has a protective effect on UC.The effectiveness is better than that of mesalazine oral only or mesalazine oral and dexamethasone retention enema.The mechanism might come by regulating the immunologic balance.