Expression and Significance of KAI1 and CD44V6 in Gastric Carcinoma

Objective To study the expression of KAI1 and CD44V6 in gastric carcinoma and its clinical significance, and to investigate their relationship. Methods SP immunohistochemistry was used to detect the expression of KAI1 and CD44V6 protein in 61 cases of gastric carcinoma tissues and 20 cases of adjacent normal gastric tissues. Results The positive rate of KAI1 in gastric carcinoma tissues was significantly lower than that of the adjacent normal gastric tissues( P 0. 05),and the positive rate of CD44V6 in gastric carcinoma tissues was significantly higher than that of the adjacent normal gastric tissues( P 0. 05). The expression of KAI1 and CD44V6 was associated with serosal invasion,the tumor stage,grade of tumor differentiation,lymph node metastasis( P 0. 05) while not related with age,and sex( P 0. 05). KAI1 expression was negatively correlated with CD44V6 expression( P 0. 01). Conclusion KAI1 and CD44V6 protein restrains each other in the happening、development、invasion and metastasis of gastric carcinoma,the detection of KAI1 and CD44V6 protein is of important value in evaluating biological behaviors of gastric carcinoma.