Observation of curative effects of Edaravone combining Batroxobin on treating acute cerebral infarction

Objective To observe the curative effects of Edaravone combining Batroxobin on treating acute cerebral infarction (ACI).Methods 86 patients with ACI were randomly divided into Edaravone+Batroxobin(united treatment)group and Batroxobin group. At the basic of routine and Batroxobin therapy,the united treatment group received Edaravone 30 mg intravenous infusion,twice a day for 14 d. Neurological deficit scale(NDS)was examined before and 7 d,14 d after treatment; the indexes of hemorheology and blood coagulation were examined before and 5 d,10 d,14 d after treatment in both groups.Results 7 d,14 d after treatment,the NDS of both groups were significantly decreased than those before treatment(P0.05-0.01). 14 d after treatment,the NDS of the united treatment group were significantly lower than that in the Batroxobin group (P0.01). The levels of fibrinogen and whole blood viscosity (low cuts) were extremely decreased on 5 d,10 d after treatment than those before treatment in both groups (all P0.01). The obvious effective rate (69.8%) and the general effective rate (95.3%) in the united treatment group were obviously higher than those in the Batroxobin group (46.5%,79.1%) (all P0.05).Conclusion Edaravone combining Batroxobin are more effective than Batroxobin only treatment for ACI.