Curative effects of edaravone combined batroxobin on treating acute cerebral infarction

Objective To observe the curative effects of edaravone combined atroxobin on treating acute cerebral infarction(ACI).Methods Eighty-two cases with ACI were randomly divided into two groups.United treatment group(49 cases) was treated with edaravone 30 mg by intervenous drop infusion,one time 12 hours,for 10 days.Meanwhile,batroxobin was given on the 1st,3rd,5th day with the dose of 10,5 and 5 BU,respectively.Batroxobin group(33 cases) was treated with batroxobin only,usage was the same as united treatment group.Neurological deficit scores(NDS) and the index of blood coagulation were examined before and after treatment in both groups.Results There was no significant difference in NDS between two groups before treatment and on the 3rd day after treatment(P0.05).On the 7th,15th day after treatment,the NDS of united treatment group was lower than batroxobin group(P0.05).The NDS of two groups decreased on the 15th after treatment than that before treatment(P0.01).The total effective rate of the united treatment group was significantly higher than that of the batroxobin group(P0.05).Fib of the two groups before treatment was significantly less than that after treatment(the united treatment group:t=19.246,P0.001;the batroxobin group:t=12.748,P0.001).Conclusion Edaravone combined batroxobin are significantly effective in the therapy on ACI and can significantly improve nerve function.