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2006•Unpublished venueRequires access

The Significance of CD147 and VEGF Expression in Esophageal Squamous Cell Carcinoma

Guang Ma

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Abstract

Objective To investigate the significance of CD147 and VEGF expression in esophageal squamous cell carcinoma. Methods The protein expression of CD147 and VEGF in 70 cases with esophageal squamous cell carcinoma were determined by immunohistochemical streptavidinperoxidase method.Results In the poor-differentiated,middle-differentiated and well-differentiated esophageal squamous cell carcinoma,the positive rate of CD147 were 87.50%,96.43%,96.15%,and the positive rate of VEGF were 87.50%,92.86%,88.46%.The expression of CD147 and VEGF had a significant relevance to infiltrating depth and lymph node metastasis,but no association was observed with pathological grades.Conclusions Both CD147 and VEGF have relevance to infiltrating depth and lymph node metastasis and clinical staging of esophageal squamous cell carcinoma.

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Objective To investigate the significance of CD147 and VEGF expression in esophageal squamous cell carcinoma. Methods The protein expression of CD147 and VEGF in 70 cases with esophageal squamous cell carcinoma were determined by immunohistochemical streptavidinperoxidase method.Results In the poor-differentiated,middle-differentiated and well-differentiated esophageal squamous cell carcinoma,the positive rate of CD147 were 87.50%,96.43%,96.15%,and the positive rate of VEGF were 87.50%,92.86%,88.46%.The expression of CD147 and VEGF had a significant relevance to infiltrating depth and lymph node metastasis,but no association was observed with pathological grades.Conclusions Both CD147 and VEGF have relevance to infiltrating depth and lymph node metastasis and clinical staging of esophageal squamous cell carcinoma.

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Available abstract

Objective To investigate the significance of CD147 and VEGF expression in esophageal squamous cell carcinoma. Methods The protein expression of CD147 and VEGF in 70 cases with esophageal squamous cell carcinoma were determined by immunohistochemical streptavidinperoxidase method.Results In the poor-differentiated,middle-differentiated and well-differentiated esophageal squamous cell carcinoma,the positive rate of CD147 were 87.50%,96.43%,96.15%,and the positive rate of VEGF were 87.50%,92.86%,88.46%.The expression of CD147 and VEGF had a significant relevance to infiltrating depth and lymph node metastasis,but no association was observed with pathological grades.Conclusions Both CD147 and VEGF have relevance to infiltrating depth and lymph node metastasis and clinical staging of esophageal squamous cell carcinoma.

Key concepts: Esophageal squamous cell carcinoma, Immunohistochemistry, Medicine, Clinical significance, Pathological, Esophageal Neoplasm, VEGF receptors, Lymph node metastasis

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