ESBLs-producing Escherichia coli and Klebsiella pneumoniae: An Antibiotic-resistance Analysis

OBJECTIVE To survey the constituent ratio and drug-resistance characteristics of ESBLs-producing bacteria-Escherichia coli and Klebsiella pneumoniae. METHODS Isolation, cultivation, identification, drug-sensitivity tests, and confirmation of ESBLs-producing bacteria were done for all the bacterial specimens collected from our hospital in 2002. Susceptibility testing was performed by disk diffusion (K-B) method. RESULTS The constituent ratios of E.coli and K.pneumoniae, which could produce ESBLs, were 43.7% and 35.3%, respectively at our hospital in 2002. The MDR (multi-drug-resistance) rate of ESBLs-producing strains was higher than that of strains no producing ESBLs (P0.05). The ESBLs-producing strains of E.coli and K.pneumoniae were sensitive to imipenem, and their resistance rates to imipenem were 4.5% and 2.1%, respectively. The resistance rates of ESBLs-producing E.coli strains to amikacin, cefoperazone/sulbactam (Sulperazon) were 24.6% to 31.4%. The resistance rate of K.pneumoniae strains to Sulperazon was 42.5%, and over 70% to other antibiotics. CONCLUSIONS The high constituent ratio of ESBLs-producing bacteria and high MDR rates make them very tough for clinical treatment of infection, which suggests that it be urgent to reducing the amount of ESBLs-producing bacteria. Wide-spectrum antibiotics should be applied strictly.