Clinical Observation of Ursodeoxycholic Acid in the Treatment of Chronic Cholestatic Viral Hepatitis B

OBJECTIVE:To observe the safety and clinical efficacy of ursodeoxycholic acid(UDCA)in the treatment of chronic cholestatic viral hepatitis B. METHODS:75 patients with chronic cholestatic viral hepatitis B were randomly divided into control group(40 cases)and observation group(35 cases). Two groups were given routine treatment of Kuhuang injection and Compound glycyrrhizin;control group was additionally given routine antiviral therapy;observation group was additionally given UDCA 250mg,tid on the basis of control group. Treatment course of 2 groups lasted for 4 weeks. Clinical efficacy,the time of digestive tract symptoms disappearance and the time of jaundice disappearance were observed in 2 groups;the changes of ALT,TBIL,ALP,GGT and adverse drug reactions were compared between 2 groups before and after treatment. RESULTS:The total effective rate of observation group was significantly higher than that of control group. The time of digestive tract symptoms disappearance and the time of jaundice disappearance in observation group were significantly lower than in control group;there was statistical significance(P0.05). There were no statistical significance in the difference of ALT,TBIL,GGT and ALP between 2 groups before treatment(P0.05). After treatment,ALT,TBIL,GGT and ALP of 2 groups were significantly lower than before;those of observation group were lower than those of control group,and there was statistical significance(P0.05). ALT of 2 groups after treatment was significantly lower than before;there was statistical significance(P0.05),but there was no statistical significance between 2groups(P0.05). No obvious ADR was found in 2 groups during treatment. CONCLUSIONS:UDCA is remarkably effective and safe treatment for chronic cholestatic viral hepatitis B.