Efficacy of Ursodeoxycholic Acid on Chronic Severe Hepatitis

Objective To observe the safety and efficacy of ursodeoxycholic acid(UDCA)in the treatment of patients with chronic severe hepatitis.Methods 58 patients with chronic severe hepatitis during early stage and medium stage were randomly divided into two groups:treatmemt group in which 29 cases were treated with UDCA in addition to conventional therapy and control group in which 29 cases were only treated with conventional therapy,with a course of four weeks.The clinical symptoms,signs and liver function were compared in the two groups before treatment,2 weeks after treatment,and at the end of the treatment.Results The clinical symptoms and liver funtion:serum bilirubin(SB),total bile acid(TBA),alkline phosphatase(ALP) and gamma glutamyl transpeptidase(GGT)in the treatment group were improved significantly at week 4 compared to the control group(P0.05).The markedly effetive rate was 41.1%,the effective rate was 27.6%,and the total effective rate was 69.0% at week 4.There was significant difference between the two groups(P0.05).No severe side-effect related to UDCA was shown.Conclusion UDCA is safe and effective in the treatment of patients with chronic severe hepatitis.