Clinical observation of Desonide cream combined with Cetaphil lotion in treatment of infantile eczema

【Objective】 To evaluate the efficacy and safety of Desonide cream combined with Cetaphil lotion in treatment of infantile eczema.【Methods】A randomized controlled open trial was performed.The combined group was applied with Desonide cream and Cetaphil lotion twice per day alternatively,and the later was maintained after the rash cured.The Desonide group was treated with Desonide cream twice per day only and the therapy was switched to once every day after the rash disappeared.The Cetaphil group was treated with Cetaphil lotion twice per day only.The variations of the rash were recorded and the total scores of erythema,papule,scale,pruritusand area were evaluated in the return visit of the same day visiting 7,14 days after medication and 7 days after recovery.【Results】The obvious effective rate with 63.93% and cure-rate with 47.54%of the combined group were significantly higher than those in Cetaphil group after 7 days of therapy,which with 91.80%and 68.85% were higher than both control groups after 14 days of therapy.But there was no statistical difference between the two control groups as to the obvious effective rate and the cure rate.【Conclusion】The results confirm Desonide cream combined with Cetaphil lotion in treatment of infantile eczema is a very effective and safe way.