ScholarLens Back to search
2002•Chinese Journal of New Drugs and Clinical RemediesRequires access

Midodrine in treatment of orthostatic hypotension

Zhao Yu-bin

Open publisher page 1 citations

Abstract

AIM: To evaluate the efficacy and safety of midodrine for orthostatic hypotension. METHODS:Twenty-nine patients with primary and secondary orthostatic hypotension participated in a multicenter, self-controlled study. The patients were treated with midodrine 5.0-7.5 mg po, qd for 5 wk. RESULTS: In the 28 evaluable patients, midodrine led to increased orthostatic systolic BP compared to that before treatment at all time points, wk 1(0.8±1.8)kPa (P0.05); wk 2(1±3)kPa (P0.05); wk 3 (1.7±2.4)kPa (P0.01); wk 4 (2±3)kPa (P0.01); wk 5 (2.7±2.6)kPa (P0.01). The BP increasing was positively related to the treatment duration. The symptom as dizziness, syncope was improved obviously(P0.01). CONCLUSION: Midodrine is effective, safe and well-tolerated drug in the treatment of orthostatic hypotension.

About this research paper

What this paper is about

AIM: To evaluate the efficacy and safety of midodrine for orthostatic hypotension. METHODS:Twenty-nine patients with primary and secondary orthostatic hypotension participated in a multicenter, self-controlled study. The patients were treated with midodrine 5.0-7.5 mg po, qd for 5 wk. RESULTS: In the 28 evaluable patients, midodrine led to increased orthostatic systolic BP compared to that before treatment at all time points, wk 1(0.8±1.8)kPa (P0.05); wk 2(1±3)kPa (P0.05); wk 3 (1.7±2.4)kPa (P0.01); wk 4 (2±3)kPa (P0.01); wk 5 (2.7±2.6)kPa (P0.01). The BP increasing was positively related to the treatment duration. The symptom as dizziness, syncope was improved obviously(P0.01). CONCLUSION: Midodrine is effective, safe and well-tolerated drug in the treatment of orthostatic hypotension.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

AIM: To evaluate the efficacy and safety of midodrine for orthostatic hypotension. METHODS:Twenty-nine patients with primary and secondary orthostatic hypotension participated in a multicenter, self-controlled study. The patients were treated with midodrine 5.0-7.5 mg po, qd for 5 wk. RESULTS: In the 28 evaluable patients, midodrine led to increased orthostatic systolic BP compared to that before treatment at all time points, wk 1(0.8±1.8)kPa (P0.05); wk 2(1±3)kPa (P0.05); wk 3 (1.7±2.4)kPa (P0.01); wk 4 (2±3)kPa (P0.01); wk 5 (2.7±2.6)kPa (P0.01). The BP increasing was positively related to the treatment duration. The symptom as dizziness, syncope was improved obviously(P0.01). CONCLUSION: Midodrine is effective, safe and well-tolerated drug in the treatment of orthostatic hypotension.

Key concepts: Midodrine, Orthostatic vital signs, Medicine, Blood pressure, Anesthesia, Internal medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Midodrine in treatment of orthostatic hypotension — Research Paper | ScholarLens