Midodrine Treatment for Patients with Hemodialysis Associated Hypotension

Objective: To evaluate efficacy of midodrine in treatment of hemodialysis associated hypotesion. Method: Midodrine(5～10mg) was employed in 16 hemodialysis associated hypotesion patients at the start of dialysis or 30 minutes before occurrences of past recorded intradialysis hypotension with same hemodialysis prescription. Result: The ultrafiltration rate, dialysate electrolyte concentration, dialysate temperature and blood pressure levels prior to dialysis were similar during pre and post midodrine administration periods(p0.05). Hematocrit and serum albumin had no statistically differences during observation period. Ultrafiltration volume, Kt/v,the lowest blood pressure intradialysis and postdialysis blood pressure were significantly higher after midodrine treatment(p0.05). Frequency of intradialysis hypotension with or without hypotensive symptom was significantly lower after midodrine treatment(p0.05). Significant efficacy in 9 of 16 patients (56.2%) and moderate efficacy in 4 of 16 patients (25%) were observed. Conclusion: Midodrine is effective in treatment of hemodialysis associated hypotension.