Effect of Black Tea on Regulating Serum Lipid in Mice Fed with a High-fat Diet

The lipid metabolic disturbance model method was used to investigate the regulatory effects of Black Tea(BT) at different dosages(5 times, 10 times and 20 times of adult daily consumption) on serum lipid levels in hyperlipoidemia mice. In present study, blood lipid levels, body weight, and related enzymes of liver and serum were measured, and the histopathological changes in tissues of liver were also examined. It was found that the serum levels of total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C), liver malondialdehyde(MDA) and liver index were significantly lower(P0.01) in BT-treated mice compared with the high hyperlipoidemia model mice, while serum levels of apo A1, lipoprotein lipase(LPL), hepatictriglyceridelipase(HL) and total lipase, and liver superoxide dismutase(SOD) actives and glutathione peroxidase(GSH-Px) actives were significantly higher after treatment with BT(P0.01). Additionally, serum levels of high density lipoprotein cholesterol(HDL-C) was slightly increased. Moreoverr, body weight was reduced, and the liver lesions were attenuated to some degree in BT-treated mice. The results suggested that BT showed a positive effect on regulating the serum lipid and reducing the liver injury induced by high fat diet.