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Significance and expression of Cyclin G in gastric carcinoma

Yang Qu

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Abstract

Objective To investigate the significance and expression of Cyclin G in gastric carcinoma.Methods Expression of Cyclin G was examined by using immunohistochemical staining SP method in 10 normal gastric tissues,52 gastric carcinoma specimens and their corresponding para-carcinoma gastric tissues.Results There was no expression identified in normal gastric tissues.Obviously positive expression in nuclear was observed in gastric carcinoma,compared to the para-carcinoma gastric tissue,low intense expression of Cyclin G was notified(P0.05).No correlation was found between the Cyclin G expression and the factor of the grade of tumor differentiation.The expression was significantly higher in those patients with lymph nodes metastasis than those without(P0.05).Conclusion The expression of Cyclin G might play a role in the carcinogenesis and progression of gastric carcinoma,make it easier to asset the condition of disease,and might become a new target for gene therapy in gastric carcinoma.

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Objective To investigate the significance and expression of Cyclin G in gastric carcinoma.Methods Expression of Cyclin G was examined by using immunohistochemical staining SP method in 10 normal gastric tissues,52 gastric carcinoma specimens and their corresponding para-carcinoma gastric tissues.Results There was no expression identified in normal gastric tissues.Obviously positive expression in nuclear was observed in gastric carcinoma,compared to the para-carcinoma gastric tissue,low intense expression of Cyclin G was notified(P0.05).No correlation was found between the Cyclin G expression and the factor of the grade of tumor differentiation.The expression was significantly higher in those patients with lymph nodes metastasis than those without(P0.05).Conclusion The expression of Cyclin G might play a role in the carcinogenesis and progression of gastric carcinoma,make it easier to asset the condition of disease,and might become a new target for gene therapy in gastric carcinoma.

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Available abstract

Objective To investigate the significance and expression of Cyclin G in gastric carcinoma.Methods Expression of Cyclin G was examined by using immunohistochemical staining SP method in 10 normal gastric tissues,52 gastric carcinoma specimens and their corresponding para-carcinoma gastric tissues.Results There was no expression identified in normal gastric tissues.Obviously positive expression in nuclear was observed in gastric carcinoma,compared to the para-carcinoma gastric tissue,low intense expression of Cyclin G was notified(P0.05).No correlation was found between the Cyclin G expression and the factor of the grade of tumor differentiation.The expression was significantly higher in those patients with lymph nodes metastasis than those without(P0.05).Conclusion The expression of Cyclin G might play a role in the carcinogenesis and progression of gastric carcinoma,make it easier to asset the condition of disease,and might become a new target for gene therapy in gastric carcinoma.

Key concepts: Gastric carcinoma, Immunohistochemistry, Carcinogenesis, Cyclin, Cancer research, Carcinoma, Medicine, Pathology

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