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2010•Journal of Tropical MedicineOpen access

Isolation of 251 Drug Resistance Strains of Mycobacteria

Zhen Zhang

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Abstract

Objective To isolate the drug-resistant Mycobacteria from clinical samples and investigate their level of antibiotic resistance.Method 251 isolates were tested for their resistance against isoniazid(INH),rifampicin(RFP),ethambutol(EMB) and streptomycin(SM).Results The rate of total drug resistance,initial drug resistance,initial multi-drug resistance,acquired drug resistance and acquired multi-drug resistance was 60.96%(153),45.10%(69),30.07%(46),85.71%(84),and 56.12%(55),respectively.The rate of resistance against INH,RFP,SM,and EMB was 49.8%,47.41%,25.1% and 18.73%,respectively.Conclusion The rate of drug resistance in this area is serious.Strengthening of the drug resistant monitoring program and to select medicine based on drug sensitivity test is important in the disease management.

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Objective To isolate the drug-resistant Mycobacteria from clinical samples and investigate their level of antibiotic resistance.Method 251 isolates were tested for their resistance against isoniazid(INH),rifampicin(RFP),ethambutol(EMB) and streptomycin(SM).Results The rate of total drug resistance,initial drug resistance,initial multi-drug resistance,acquired drug resistance and acquired multi-drug resistance was 60.96%(153),45.10%(69),30.07%(46),85.71%(84),and 56.12%(55),respectively.The rate of resistance against INH,RFP,SM,and EMB was 49.8%,47.41%,25.1% and 18.73%,respectively.Conclusion The rate of drug resistance in this area is serious.Strengthening of the drug resistant monitoring program and to select medicine based on drug sensitivity test is important in the disease management.

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Available abstract

Objective To isolate the drug-resistant Mycobacteria from clinical samples and investigate their level of antibiotic resistance.Method 251 isolates were tested for their resistance against isoniazid(INH),rifampicin(RFP),ethambutol(EMB) and streptomycin(SM).Results The rate of total drug resistance,initial drug resistance,initial multi-drug resistance,acquired drug resistance and acquired multi-drug resistance was 60.96%(153),45.10%(69),30.07%(46),85.71%(84),and 56.12%(55),respectively.The rate of resistance against INH,RFP,SM,and EMB was 49.8%,47.41%,25.1% and 18.73%,respectively.Conclusion The rate of drug resistance in this area is serious.Strengthening of the drug resistant monitoring program and to select medicine based on drug sensitivity test is important in the disease management.

Key concepts: Ethambutol, Drug resistance, Rifampicin, Streptomycin, Isoniazid, Drug, Medicine, Antibiotics

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