Analysis on drug resistance of mycobacterium tuberculosis in Fengxian district Shanghai

To understand primary and acquired drug resistance of mycobacterium tuberculosis. M.tuberculosis positive sputum samples were collected from January 2002 to July 2003. Ameliorative Lowenstein-Jensen' culture medium was used to detect bacillus-positive specimen of pulmonary tuberculosis. 214 samples were affirmed. Drug susceptibility test against streptomycin(SM), isoniazid (INH),rifampicin (RFP), ethambutol (EMB) and sodium para-aminosalicylate (PAS) were tested. The total drug resistance rate was 39.25% (84/214), the initial drug resistance rate was 11.83% (11/93), the initial multi-drug resistance rate was 7.53% (7/93), the acquired and multi-drug resistance(MDR) rate were 60.33% (73/121) .MDR-TB rate was 49.93% (58/121). SM and INH were primary and secondary resistance drugs, the rates were 75.00% (63/84) and 63.10% (53/84). [Conclusion] The acquired drug resistant and multi-drug resistant rates were higher than the initial drug resistance rate. Drug sensitivity surveillance on mycobacteria tuberculous should be further strengthened.