Drug resistance of Mycobacterium tuberculosis in Yan'an

Objective To investigate initial and acquired drug resistance of Mycobacterium tuberculosis.Methods Tuberculosis positive sputum samples were collected from January 2006 to January 2008.Ameliorative Lowenstein-Jensen culture medium was used to detect bacillus-positive specimen of pulmonary tuberculosis.A total of 144 samples were affirmed.Drug susceptibility tests against streptomycin(SM),isoniazid(INH),rifampicin(RFP),ethambutol(EMB)and sodium para-aminosalicylate(PAS)were detected.Results The total drug resistance rate was 42.36%(61/144).The initial drug resistance rate and initial multi-drug resistance rate were 14.29%(9/63)and 9.52%(6/63),respectively.The acquired drug resistance rate and acquired multi-drug resistance(MDR)rate were 64.20%(52/81)and 38.27%(31/81),respectively.RFP and INH were primary and secondary resistance drugs,and the drug resistance rates were 36.11%(52/144)and 33.33%(48/144),respectively.Conclusion The acquired drug resistant rate is higher than the initial drug resistance rate.Drug sensitivity of Mycobacteria tuberculousis should be monitored.