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2006•Chinese Journal of Laboratory DiagnosisRequires access

The effect of PRA level in pre-immuned recipient on early rejection after kidney transplantation

Guo Bao-fu

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Abstract

Objective To study the relationship between the population reactive antibody(PRA) level in pre-immuned recipients before kidney transplantation and early rejection aftrer transplantation.Methods The PRA level of 321 patients were tested by ELISA;donor and recipient HLA class I typing was performed with monoclonal antibody tray and HLA class II gene typing with Micro-sequence-specific-primers(Micro-SSP).Results The incidence of early rejection in the PRA negative group was much lower than that of pre-immuned group,and so was with the HLA matching group lower than HLA un-matching group.Conclusion PRA play an important role in early rejection after kidney transplantation.It will be possible to reduce early rejection by lowering the level of PRA and selecting suitable HLA matching donor.

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What this paper is about

Objective To study the relationship between the population reactive antibody(PRA) level in pre-immuned recipients before kidney transplantation and early rejection aftrer transplantation.Methods The PRA level of 321 patients were tested by ELISA;donor and recipient HLA class I typing was performed with monoclonal antibody tray and HLA class II gene typing with Micro-sequence-specific-primers(Micro-SSP).Results The incidence of early rejection in the PRA negative group was much lower than that of pre-immuned group,and so was with the HLA matching group lower than HLA un-matching group.Conclusion PRA play an important role in early rejection after kidney transplantation.It will be possible to reduce early rejection by lowering the level of PRA and selecting suitable HLA matching donor.

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Available abstract

Objective To study the relationship between the population reactive antibody(PRA) level in pre-immuned recipients before kidney transplantation and early rejection aftrer transplantation.Methods The PRA level of 321 patients were tested by ELISA;donor and recipient HLA class I typing was performed with monoclonal antibody tray and HLA class II gene typing with Micro-sequence-specific-primers(Micro-SSP).Results The incidence of early rejection in the PRA negative group was much lower than that of pre-immuned group,and so was with the HLA matching group lower than HLA un-matching group.Conclusion PRA play an important role in early rejection after kidney transplantation.It will be possible to reduce early rejection by lowering the level of PRA and selecting suitable HLA matching donor.

Key concepts: Human leukocyte antigen, Kidney transplantation, Immunology, Transplantation, Monoclonal antibody, Panel reactive antibody, Medicine, Population

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The effect of PRA level in pre-immuned recipient on early rejection after kidney transplantation — Research Paper | ScholarLens