The Effects of Ischemic Postconditioning on Cardiac Function and Serum SOD,MDA during Ischemia-reperfusion of Myocardium in Rabbits

Objective: To investigate the effects of ischemic postconditioning on cardiac function and serum SO,MDA during ischemia-reperfusion of myocardium in rabbits.Methods: Twenty-four New Zealand white rabbits were divided randomly into 3 groups(8 in each): Sham-operated group(A),ischemia-reperfusion group(B),and ischemic postconditioning group(C).Cardiac function were evaluated with cardiac hemodynamic indexes;SOD and MDA in serum were assayed.Results: Compared with group B,left ventricular systolic pressure(LVSP) and maximal changing rate of left ventricular inner pressure(±dp /dtmax) increased remarkably in group C in 180 min after reperfusion(P0.05),and left ventricular end-diastolic volume(LVEDP) decreased significantly(P0.05);Serum MDA level in group B was significantly higher(P0.01),while SOD level was significantly lower than those in group A(P0.01);In group C,MDA level was significantly lower(P0.01) but SOD level was higher than those of group B(P0.05).Conclusion: Ischemic postconditioning could improve cardiac function during ischemia-reperfusion injury in rabbits,of which the potential mechanism might involve anti-oxidization and reduction of free radical caused injury.