2015•Zhongguo yaofangRequires access
Clinical Observation of Shuxuetong Combined with Butylphthalide in the Treatment of Acute Massive Cerebral Infarction in Elderly Patients
Lao Jia-lian
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Abstract
OBJECTIVE:To observe therapeutic efficacy and safety of shuxuetong combined with butylphthalide in the treatment of elderly acute massive cerebral infarction. METHODS:76 elderly patients with acute massive cerebral infarction selected were randomly divided into observation group and control group,with 38 cases in each group. Control group was treated with butylphthalide,100 ml,bid;observation group was additionally given shuxuetong 6 ml added into 55 Glucose injection 200 ml,ivgtt,qd,on the basis of control group. The NIHSS,coagulation index,hematocrit,platelet aggregation rate and clinical efficacy were observed in 2 groups before and after treatment. RESULTS:After 14 d treatment,NIHSS of observation group [(3.57±0.25)points] was significantly lower than that of control group [(5.98±1.13)points],with statistical significance(P0.05);after treatment,total effective rate of observation group(81.58%)was significantly higher than that of control group(57.89%),with statistical significance(P0.05);platelet aggregation rate [(52.38±3.74)%] and hematocrit [(36.21±3.26)%] of observation group were significantly lower than those of control group,with statistical significance(P0.05). Before and after treatment,coagulation indexes of both groups had no significant change,without statistical significance(P0.05). No obvious ADR was found in 2groups. CONCLUSIONS:Shuxuetong combined with butylphthalide is effective in the treatment of elderly acute massive cerebral infarction,and help restore neurological function with good safety.