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2003•Chinese Journal of NeuromedicineRequires access

The research progress of ornithine decarboxylase and its gene expression in human glioma

Haiyan Hu

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Abstract

Ornithine decarboxylase (ODC) is the first metabolic key enzyme of polyamine metabolism, and the activity of ODC represent biochemical markers of malignancy in glioma. The induction of ODC-gene is closely associated with tumor cell proliferation and invasion, so the ODC-gene has characteristics of oncogenes. Difluoromethylornithine (DFMO), a specific inhibitor of ornithine decarboxylase and the antizyme (AZ)which targets ODC might have potential therapeutical effect for human glioma.

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What this paper is about

Ornithine decarboxylase (ODC) is the first metabolic key enzyme of polyamine metabolism, and the activity of ODC represent biochemical markers of malignancy in glioma. The induction of ODC-gene is closely associated with tumor cell proliferation and invasion, so the ODC-gene has characteristics of oncogenes. Difluoromethylornithine (DFMO), a specific inhibitor of ornithine decarboxylase and the antizyme (AZ)which targets ODC might have potential therapeutical effect for human glioma.

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Available abstract

Ornithine decarboxylase (ODC) is the first metabolic key enzyme of polyamine metabolism, and the activity of ODC represent biochemical markers of malignancy in glioma. The induction of ODC-gene is closely associated with tumor cell proliferation and invasion, so the ODC-gene has characteristics of oncogenes. Difluoromethylornithine (DFMO), a specific inhibitor of ornithine decarboxylase and the antizyme (AZ)which targets ODC might have potential therapeutical effect for human glioma.

Key concepts: Ornithine decarboxylase, Ornithine decarboxylase antizyme, Eflornithine, Polyamine, Glioma, Biology, Cancer research, Enzyme

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