Comparative Study of XSJZW on the Effects on Hemorheology in Rat Model of Acute Blood Stasis

ObjectiveTo observe and compare the effects of XSJZW with FFDSP on the hemorheology and platelet aggregation in acute blood-stasis model rats.Methods60 SD rats were divided into 6 groups at random by SAS,the rats were pre-treated with drug or 0.3%CMC by lavage respectively according to the regulation,soaked after injection s.c with 0.08mg/100g adrenine into ice water for 5min to prepare rat model of acute blood stasis.Then the parameters of hemorheology and platelet aggregation were determined.ResultsThe XSJZW groups could obviously decrease the levels of blood viscosity high 、low shears ,blood reduce viscosity high 、low shears,hematocrit,index of erythrocyte aggregation,fibrinogen(P0.01 or P0.05),and increase those of index of erythrocyte deformability(P0.05),inhibit platelet aggregation,improve some parameters,XSJZW groups were better than FFDSP(P0.05),the dose-dependence was observed among the XSJZW groups.ConclusionThe XSJZW groups can significantly improve hemorheology and hypercoagulabale state of blood and inhibit platelet aggregation in acute blood-stasis model rats,and is beneficial to prevent and treat the development of coronary artery disease and its complications.