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Effects of Xiangdan Injection on Hemorheology and Platelet Aggregation in Acute Blood Stasis Rats

XU Kang-kang

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Abstract

Objective:To study the effects of Xiangdan Injection on hemorheology and platelet aggregation in acute blood stasis rats.Method:The acute blood stasis rats model was established by subcutaneous injection of high-dose adrenaline hydrochloride and being socked in ice-water.Then the model rats were treated with drugs by in-travenous injection.The blood samples were taken through common carotid artery(CCA) at 0.5 hours after last ad-ministration.Viscosity of blood and plasma,content of fibrinogen and the rates of platelet aggregation were deter-mined.Result: Xiangdan Injection could not only reduce viscosity of whole blood,erythrocyte aggregation index,viscosity of plasma and content of fibrinogen,but also remarkably inhibit the rates of platelet aggregation in model rats.Conclusion: Xiangdan Injection obviously ameliorates the hemorheology and inhibits platelet aggregation in a-cute blood stasis rats.

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Objective:To study the effects of Xiangdan Injection on hemorheology and platelet aggregation in acute blood stasis rats.Method:The acute blood stasis rats model was established by subcutaneous injection of high-dose adrenaline hydrochloride and being socked in ice-water.Then the model rats were treated with drugs by in-travenous injection.The blood samples were taken through common carotid artery(CCA) at 0.5 hours after last ad-ministration.Viscosity of blood and plasma,content of fibrinogen and the rates of platelet aggregation were deter-mined.Result: Xiangdan Injection could not only reduce viscosity of whole blood,erythrocyte aggregation index,viscosity of plasma and content of fibrinogen,but also remarkably inhibit the rates of platelet aggregation in model rats.Conclusion: Xiangdan Injection obviously ameliorates the hemorheology and inhibits platelet aggregation in a-cute blood stasis rats.

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Available abstract

Objective:To study the effects of Xiangdan Injection on hemorheology and platelet aggregation in acute blood stasis rats.Method:The acute blood stasis rats model was established by subcutaneous injection of high-dose adrenaline hydrochloride and being socked in ice-water.Then the model rats were treated with drugs by in-travenous injection.The blood samples were taken through common carotid artery(CCA) at 0.5 hours after last ad-ministration.Viscosity of blood and plasma,content of fibrinogen and the rates of platelet aggregation were deter-mined.Result: Xiangdan Injection could not only reduce viscosity of whole blood,erythrocyte aggregation index,viscosity of plasma and content of fibrinogen,but also remarkably inhibit the rates of platelet aggregation in model rats.Conclusion: Xiangdan Injection obviously ameliorates the hemorheology and inhibits platelet aggregation in a-cute blood stasis rats.

Key concepts: Hemorheology, Blood stasis, Erythrocyte aggregation, Fibrinogen, Chemistry, Platelet, Platelet aggregation, Plasma viscosity

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