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Effects of Corticosteroid on Expression of Nerve Growth Factor in Lungs of Asthmatic Rats

Han Su-ge

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Abstract

Objective To investigate the role of nerve growth factor(NGF)in asthmatic rats by observing the expression of NGF and effects of corticosteroid on the expression of NGF in lungs of asthmatic rats.Methods Forty-five rats were randomly devided into 3 groups:control group,asthmatic group,therapeutic group with corticosteroid.The thickness of airway smooth musle(ASM)was measured by HE staining,and the expression of NGF was observed by immunohistochemical staining.Results 1.The thickness of ASM,the expression of NGF and were significantly higher in asthmatic group than those of control group and therapeutic group(Pa0.05).2.It was much higher in therapeutic group than those in control group(P0.05).3.There was a positive relationship between the level of expression of NGF and the thickness of ASM.Conclusion The expression of NGF increased in the lung tissues of asthmatic rats,and corticosteroid can reduce the expression of NGF.

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What this paper is about

Objective To investigate the role of nerve growth factor(NGF)in asthmatic rats by observing the expression of NGF and effects of corticosteroid on the expression of NGF in lungs of asthmatic rats.Methods Forty-five rats were randomly devided into 3 groups:control group,asthmatic group,therapeutic group with corticosteroid.The thickness of airway smooth musle(ASM)was measured by HE staining,and the expression of NGF was observed by immunohistochemical staining.Results 1.The thickness of ASM,the expression of NGF and were significantly higher in asthmatic group than those of control group and therapeutic group(Pa0.05).2.It was much higher in therapeutic group than those in control group(P0.05).3.There was a positive relationship between the level of expression of NGF and the thickness of ASM.Conclusion The expression of NGF increased in the lung tissues of asthmatic rats,and corticosteroid can reduce the expression of NGF.

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Available abstract

Objective To investigate the role of nerve growth factor(NGF)in asthmatic rats by observing the expression of NGF and effects of corticosteroid on the expression of NGF in lungs of asthmatic rats.Methods Forty-five rats were randomly devided into 3 groups:control group,asthmatic group,therapeutic group with corticosteroid.The thickness of airway smooth musle(ASM)was measured by HE staining,and the expression of NGF was observed by immunohistochemical staining.Results 1.The thickness of ASM,the expression of NGF and were significantly higher in asthmatic group than those of control group and therapeutic group(Pa0.05).2.It was much higher in therapeutic group than those in control group(P0.05).3.There was a positive relationship between the level of expression of NGF and the thickness of ASM.Conclusion The expression of NGF increased in the lung tissues of asthmatic rats,and corticosteroid can reduce the expression of NGF.

Key concepts: Nerve growth factor, Corticosteroid, Immunohistochemistry, Medicine, Internal medicine, Endocrinology, Therapeutic effect, Staining

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