Expressions and clinical significance of P-gp and p53 in lung cancer tissues

Objective To evaluate the expression level and its clinical significance of P-gp and p53 in lung cancer tissue.Methods To use the method of immunohistochemical techniques to test the expression level of P-gp and p53 about 40 lung cancer tissue specimen who had the chemotherapy history and 44 lung cancer tissues of non-chemotherapy history , and visited the survival time, comparing the relationship between the expression of P-gp,p53 and the survival rate.Results The positive expression rate of P-gp in lung cancer tissue was 40.5%,The positive expression rate of p53 was 70.2%. P-gp and p53 had no correlation in the expression of lung cancer tissues (P=0.673);And the survival time of the patients with lung cancer who was accepted chemotherapy in the positive expression of P-gp and p53 was shorter than that of the negative expression of P-gp and p53 (P0.05).Conclusion P-gp and p53 can be taken for a reference index to judge the clinical effect of the chemotherapy and make prognosis of the patients with lung cancer.