Expression and clinical significance of multi-drug resistance associated protein and P-glycoprotein in non-small-cell lung cancer

Objective To observe the expression of the multi-drug resistance associated protein(MRP) and P-glycoprotein(P-gp) in non-small cell lung cancer(NSCLC) tissues, and the relationship between MRP,P-gp and the prognosis of patients' conditions. Methods The expressions of MRP and P-gp in NSCLC were measured by using the S-P immunohistochemistry. Results Among the 42 cases, the positive rate of MRP in NSCLC was 45.2%,the expression of MRP in adeno-carcinoma was higher than that in squamous carcinoma(P 0.05); the positive rate of P-gp in lung cancer tissue was 40.4%,the expression of P-gp was not related to patients' sex,age,clinical stage, differentiation degree of tumor cells(P 0.05),the expressions of P-gp and MRP had positive correlation in lung cancer (P 0.01). The non-tumor survival rate of three year postoperative of negative patients with MRP and P-gp in lung cancer was longer than that in the positive patients with MRP and P-gp (P 0.05). Conclusion P-gp and MRP can be taken for a referential index to judge the clinical effect of the chemotherapy and evaluate prognosis of patients with lung cancer.