2014•Central South PharmacyRequires access

Rosiglitazone compound formula eliminates the side effects of rosiglitazone

Wang Li-l

Abstract

Objective To investigate whether rosiglitazone compound formula could eliminate the side effects of rosiglitazone and to investigate the possible mechanism. Methods We researched the blood volume, kidney and heart function after administering rosiglitazone formula in normal rats by measuring different biochemical indicators. All the data were statisticaly analyzed by SPSS 13.0. Results Rosiglitazone decreased HCT, ALB and ALD concentration, and impacted electrolyte concentration. Luckily, rosiglitazone formula RSGF group were without above phenomena. Conclusion Rosiglitazone may induce side effects by regulating serum ALB and ALD concentration, while rosiglitazone compound formula can eliminate the side effects of rosiglitazone.

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Available abstract

Key concepts: Rosiglitazone, Medicine, Internal medicine, Pharmacology, Chemistry, Endocrinology, Receptor