2010•Zhonghua neifenmi daixie zazhiRequires access
Effects of rosiglitazone on the atherosclerosis and oxidative stress in diabetic rabbits
Li Luo, Liyong Yang, XU Chang-sheng
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Abstract
Rosiglitazone was used for intervention of atherosclerosis in diabetic rabbits.The results showed that the intima/medium thickness ratio,cross section area of plaque,and the expressions of NADPH oxidase p22phox,gp91 phox were decreased;while the total anti-oxidative ability was increased after administration of rosiglitazone as compared with the non-intervention group(all P<0.05).Compared with rosiglitazone treatment group,serum hepatocuprein leveI in rosiglitazone prevention group was increased,while serum malonaldehyde level decreased(both P<0.05).This study suggests that rosiglitazone may have the effect of reducing the oxidative stress and the formation of atherosclerotic plaque in diabetics.
Key words:
Diabetes; Atheroselerosis; Rosiglitazone; Oxidative stress