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2001•Acta Academiae Medicinae JiangxiRequires access

The Classification in Vitro and Observations on Clinical Treatment of Aplastic Anemia

Hong Xiong

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Abstract

Objectives: To explore the classification in vitro by pathogenesis and to observe the clinical treatment of aplastic anemia (AA). Methods: Bone marrow mono-nucleus cells (BMMNC) were cultured in methylcellulose semisolid medium. The patients with AA, divided into different groups by random, were treated with androgen or combined androgen and cyclosporin A (CSA). Results: There were three types of BMMNC in AA patients as follows: stem cells defect, immune mediation and microenvironmental defect. Among them, the type of stem cells defect was more. The curative effect of combined androgen and CSA was better than that of androgen ( P ＜0.01). Conclusions: The pathogenesis of AA is different. The value of CSA in the treatment of AA is worth further studying.

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Objectives: To explore the classification in vitro by pathogenesis and to observe the clinical treatment of aplastic anemia (AA). Methods: Bone marrow mono-nucleus cells (BMMNC) were cultured in methylcellulose semisolid medium. The patients with AA, divided into different groups by random, were treated with androgen or combined androgen and cyclosporin A (CSA). Results: There were three types of BMMNC in AA patients as follows: stem cells defect, immune mediation and microenvironmental defect. Among them, the type of stem cells defect was more. The curative effect of combined androgen and CSA was better than that of androgen ( P ＜0.01). Conclusions: The pathogenesis of AA is different. The value of CSA in the treatment of AA is worth further studying.

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Available abstract

Objectives: To explore the classification in vitro by pathogenesis and to observe the clinical treatment of aplastic anemia (AA). Methods: Bone marrow mono-nucleus cells (BMMNC) were cultured in methylcellulose semisolid medium. The patients with AA, divided into different groups by random, were treated with androgen or combined androgen and cyclosporin A (CSA). Results: There were three types of BMMNC in AA patients as follows: stem cells defect, immune mediation and microenvironmental defect. Among them, the type of stem cells defect was more. The curative effect of combined androgen and CSA was better than that of androgen ( P ＜0.01). Conclusions: The pathogenesis of AA is different. The value of CSA in the treatment of AA is worth further studying.

Key concepts: Aplastic anemia, Pathogenesis, In vitro, Androgen, Medicine, Bone marrow, Stem cell, Anemia

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