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2010•Jiguang shengwu xuebaoRequires access

Mutagenesis of Strain with High Yield of Kojic Acid

Xin Zhao, Zhao Hui Jin, HU Cui-min, Zongbao K. Zhao

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Abstract

The kojic acid-producing strain Aspergillus flavus CICC 2 242 was mutagenized using UV radiation and N~+ implantation,and its mutant strain A.flavus N83 was obtained.The mutant strain produced kojic acid at 19.4 g/L, which was 56.5%higher than that with A.flavus CICC 2 242 at 12.4 g/L.Moreover,A.flavus N83 showed good genetic stability.The results showed that N~+ implantation was an effective method to generate better kojic acid producer.

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What this paper is about

The kojic acid-producing strain Aspergillus flavus CICC 2 242 was mutagenized using UV radiation and N~+ implantation,and its mutant strain A.flavus N83 was obtained.The mutant strain produced kojic acid at 19.4 g/L, which was 56.5%higher than that with A.flavus CICC 2 242 at 12.4 g/L.Moreover,A.flavus N83 showed good genetic stability.The results showed that N~+ implantation was an effective method to generate better kojic acid producer.

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Available abstract

The kojic acid-producing strain Aspergillus flavus CICC 2 242 was mutagenized using UV radiation and N~+ implantation,and its mutant strain A.flavus N83 was obtained.The mutant strain produced kojic acid at 19.4 g/L, which was 56.5%higher than that with A.flavus CICC 2 242 at 12.4 g/L.Moreover,A.flavus N83 showed good genetic stability.The results showed that N~+ implantation was an effective method to generate better kojic acid producer.

Key concepts: Kojic acid, Aspergillus flavus, Strain (injury), Mutant, Yield (engineering), Mutagenesis, Chemistry, Biochemistry

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