Efficacy comparison of paroxetine combined with quetiapine or risperidone in the treatment of refractory depression

Objective To explore the efficacy of paroxetine combined with quetiapine or risperidone in treatment-refractory depression. Methods 120 patients with refractory depression were selected and randomly divided into observation group and control group. The observation group was given paroxetine combined with quetiapine while the control group was given paroxetine combined with risperidone, the Hamilton Depression Scale(HAMD)was used in the two groups of patients before and after treatment, and Treatment Emergent Symptom Scale(TESS) was used to measure the adverse reaction of the treatment. Results Hamilton Depression Scale scores were lower in the observation group after treatment of second weeks, fourth weeks and sixth weeks compared with those in the control group, the difference was statistically significant(P0.05). The occurrence rate of adverse reaction in the observation group during treatment was 5%; the rate of adverse reactionin the control group during treatment was 18.3%; the adverse reaction rate in the control group was higher than that in the observation group, and the difference was statistically significant(P0.05). Conclusion Effect of paroxetine combined with quetiapine in refractory depression is better than combined with risperidone, which has lower occurrence rate of adverse reaction as well and and could be one valuable augmentation in refractory depression.