2004•Journal of OncologyRequires access

An Analysis of Oxaliplatin Combined with Fluorouracil and Leucovorin in 40 Cases with Advanced Gastric Cancer

Yan Sun

Abstract

To evaluate the short-term efficacy and side effect of oxaliplatin combined with fluo-rouracil(5-Fu)and leucovorin(CF)in advanced gastric cancer.Forty cases with advanced gas-tric cancer were received oxaliplatin130mg/m 2 (2hours intravenous infusion in the first day)and CF200mg/m 2 followed by5-Fu500mg/m 2 (30minutes infusion)then5-Fu2.0g/m 2 (48hours continuous in-fusion)every three weeks.The efficacy were analyzed after two therapeutic cycles completed.The overall response rate was45.0%(CR,2cases;PR,16cases).Peripheral neuropathy was the main side effect(75%).[Conclusion]The oxaliplatin/5-Fu/CF regimen shows good efficacy with mild toxicity in treatment advanced gastric cancer.

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Key concepts: Oxaliplatin, Medicine, Regimen, Fluorouracil, Cancer, Toxicity, Internal medicine, Gastroenterology