Study on Acute Toxicity of Sulfaquinoxalinum to Mice

To study the toxicity of Sulfaquinoxalinum to the mice by oral administration.LD50 of Sulfaquinoxalinum in mice was determined by modified Karber's method.Mice were divided into 5 groups randomly,administered with different dose Sulfaquinoxalinum and 0.9% sodium chloride solution.The clinical symptoms and activity of mice macrophages phagocytosing chicken erythrocytes were observed,at the same timewiviscera index was calculated.LD50 of Sulfaquinoxalinum to the mice by oral administration was 4889.90 mg/kg,with the 95% confidence limit of 5471.71~4308.09 mg/kg.The activity of mice macrophages phagocytosing chicken erythrocytes decreased.The indexes of heart and spleen decreased,while the indexes of liver and kidney increased.The main pathological changes were as follow: heart coloured on,myocardial fibers swelled;liver and kidney enlarged obviously,renal tubular epithelial cells swelled and degenerated,some tubular epithelial cells fractured;splenomegaly,spleen body atrophy,lymphocyte decreased.After mice were poisoned with Sulfaquinoxalinum,activity of nonspecific immunity dropped.The main organs,such as heart,liver,spleen and kidney were harmed in certain extent.