Experimental Research of Therapentic Effect of Ganxining Capsule on Expermental HF Rats

Objective:To observe the preventive and therapeutic effect of Ganxining capsule on experimental HF rats.Methods:52 SD rats were randomly divided into 5 groups ,the normal group,the model group,the positive control group,the high dose group,and the low dose group.HF rat model was duplicated with Improved Composite Factor Method.Rats of the normal group and the model group were administered normal sodium with dose 10mL/kg,positive control group were administered Colchicine with the dose 0.125mg/kg.The high dose group and the low dose group were administered Ganxining with the dose 26,6.5g/kg respectively.The liver pathology change of each group by HE coloration were compared 6 weeks later.Results:Compared with the model group,each treated group has significant difference in the HF degree (P0.05 or P0.01),the low dose group is the most significant difference in all groups(P0.01).Compared with the model group,the high dose group and the low dose group has significant difference in hepar adiposum (P0.05 or P0.01),but the positive control group has not the significant difference (P0.05).Conclusion:Ganxining capsule could effectively prevent HF of the experimental rats.It is inadvisable for Chinese medicine to treat HF by only increasing the drug quantity.