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2000•Acta Universitatis Medicinalis Secondae ShanghaiRequires access

Effects of GnRHa on ER, PR and Epidermal Growth Factor- Receptor in Uterine Leiomyoma

Qi-de Lin

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Abstract

Objective To study the effect of GnRHa on ER、PR and EGF-R in uterine leiomyoma. Methods ER、PR and EGF-R in uterine leiomyoma in 13 patients (study group) who had been treated with GnRHa 150μg/d for 3 months before operation were compared with 28 patients (control group) in whom no GnRHa was taken. Results The ER, PR and EGF-R in the GnRHa treated patients were significantly lower than those in the control group. Conclusion In addition to decreasing the ER and PR content, GnRHa can reduce the EGF-R level in leiomyoma. This may be an important therapeutic mechanism of GnRHa.

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What this paper is about

Objective To study the effect of GnRHa on ER、PR and EGF-R in uterine leiomyoma. Methods ER、PR and EGF-R in uterine leiomyoma in 13 patients (study group) who had been treated with GnRHa 150μg/d for 3 months before operation were compared with 28 patients (control group) in whom no GnRHa was taken. Results The ER, PR and EGF-R in the GnRHa treated patients were significantly lower than those in the control group. Conclusion In addition to decreasing the ER and PR content, GnRHa can reduce the EGF-R level in leiomyoma. This may be an important therapeutic mechanism of GnRHa.

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Available abstract

Objective To study the effect of GnRHa on ER、PR and EGF-R in uterine leiomyoma. Methods ER、PR and EGF-R in uterine leiomyoma in 13 patients (study group) who had been treated with GnRHa 150μg/d for 3 months before operation were compared with 28 patients (control group) in whom no GnRHa was taken. Results The ER, PR and EGF-R in the GnRHa treated patients were significantly lower than those in the control group. Conclusion In addition to decreasing the ER and PR content, GnRHa can reduce the EGF-R level in leiomyoma. This may be an important therapeutic mechanism of GnRHa.

Key concepts: Leiomyoma, Uterine leiomyoma, Epidermal growth factor, Medicine, Internal medicine, Uterus, Endocrinology, Receptor

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