Changes of apoptosis regulating gene Bcl-2 in cases with hysteromyoma after gonadotrophin releasing hormone agonist treatment

Objective:To explore the effect of gonadotrophin releasing hormone agonist(GnRHa) on apoptosis regulating gene Bcl-2 in hysteromyoma and adjacent tissues.Methods:30 cases with hysteromyoma were treated with GnRHa(triptorelin,3.75 mg/28 days) for 2～4 months,immunochemical method was used to detect the expression levels of apoptosis regulating gene Bcl-2 in hysteromyoma and adjacent tissues at 4～6 weeks after the last injection,30 cases with hysteromyoma receiving operation at the same time were selected as control group.Results:The volumes of uterus and hysteromyoma in GnRHa group decreased significantly,the shrinking rates of uterus and hysteromyoma were(42.77±12.11)% and(37.65±15.20)%,respectively;the expression level of Bcl-2 in uterine leiomyoma cells of GnRHa group was significantly lower than that in control group(P0.01),there was no significant difference in expression level of Bcl-2 between myometrial tissues of GnRHa group and control group(P0.05).Conclusion:The decrease of Bcl-2 expression in uterine leiomyoma cells may be one of the important mechanisms of hysteromyoma regression after treatment with GnRHa.