Clinical observation on analgesic effect and safety of dezocine after endoscopic nasal surgery

Objective To observe the analgesic effect and safety of dezocine after endoscopic nasal surgery by two different methods of administration. Methods 96 patients received endoscopic nasal surgery were randomly divided into group A,B and C. After operation,the patients in group A,B and C were given no painkiller, intravenous injections of dezocine( 10 mg) and intramuscular injection of dezocine( 10 mg) respectively. Visual analog scale( VAS) was used for rating the level of pain at time-points of 30 min,1,2,4 and 6 h after the patients regained consciousness. Adverse effects in all patients were observed and recorded. Results The VAS scores of both group B and C at 0. 5,1,2,4 and 6 h were lower than those of group A( all P 0. 05). The differences of VAS scores between group B and C at 0. 5,2 and 4 h were insignificant,while those at 1 and 6 h were significant. The incidence of postoperative nausea,vomiting and respiratory inhibition of group A and group C was lower than those of group B( P 0. 05),and the differences between group A and B,C and B were insignificant respectively. There were no significant differences in the incidence of somnolence and dizziness among the 3 groups. Conclusions Intravenous and intramuscular injections of dezocine can provide good analgesic effect after endoscopic sinus surgery. The short-term effect provided by intravenous injection is superior to that by intramuscular injection,but intramuscular injection of dezocine could extend duration of good analgesic effect with lower incidence of adverse reactions. Therefore,dezocine injected intramuscularly maybe a safe analgesic for postoperative analgesic therapy in endoscopic nasal surgery.