Analysis on the factors influencing the prognosis of chronic severe hepatitis treatment by artificial liver support system

Objective: To explore the prognostic factors on patients with chronic severe hepatitis treatment by artificial liver support system by analyzing the clinical date of 65 cases with chronic severe hepatitis treatment by artificial liver support system. Methods Clinical data of 65 patients with chronic severe hepatitis treatment by artificial liver support system were analyzed retrospectively. Results Fatality rate in patients with severe hepatitis had no relation to age and sexuality. There is no significant difference between the death rate of patients with single infection of HBV and that of patients with multiple infection of HBV and other type hepatitis virus. Hepatic encephalopathy (86.49%), hepatorenal syndrome(40.54%), severe infection(27.03%)and primary peritonitis (64.86%)in death group were higher than those in curing or improving group(35.71%, 10.71%, 3.57%, 39.29%, P0.05)。.Prothrombrin activity (PTA) (26.29±13.75)and cholesterol (CHOL) (1.27±0.66) in death group was lower than that in curing or improving group(32.93±7.38, 2.21±1.06, P0.05). Conclusion Low PTA, low CHOL, and complicated with hepatic encephalopathy, hepatorenal syndrome, severe infection and primary peritonitis are bad parameters in patients with chronic severe hepatitis treatment by artificial liver support system.